Therefore, in this paper, we investigated the protective effect of aerobic exercise on infarcted heart function by regulating miR-133a and further influencing CTGF expression, which provides a new experimental and theoretical basis for an in-depth study of the pathological development process of the infarcted heart and offers possible targets and ideas for exploring screening tools and methods for myocardial infarction prevention and treatment. This evidence concerns the gene CCN2 and myocardial infarction.