The results showed that the LRS-high and MRS-low groups were positively correlated with multiple tumor suppression–related pathways and immune activation–related pathways, such as the P53 pathway, apoptosis pathway, inflammatory response pathway, antigen processing and presentation pathway, and TNF signaling, while the LRS-low and MRS-high groups were positively correlated with multiple tumor promoting–related pathways and metabolism-related pathways, including MYC target signaling, E2F target signaling, and glucolipid metabolism (Figure 4 and Supplemental Figure 7). This evidence concerns the gene TNF and neoplasm.