Moreover, miR-6884-5p mimics also attenuated the expression of S100A16 in A549 cells, conversely overexpression of S100A16 in A549 cells, could reverse the inhibitory effect of miR-6884-5p on the expressions of MMP2, N-cadherin, and E-cadherin, which suggested that miR-6884-5p regulated EMT progression through S100A16, leading to the management of NSCLC. Here, CDH2 is linked to non-small cell lung carcinoma.