Given the reported antidiabetogenic and antiinflammatory effects of FGF21, we explored how other adipokines/cytokines might be affected by the extreme and chronic elevations of FGF21 in the MMA patient cohort and whether adipose accumulation was associated with inflammatory markers/cytokines causally linked to insulin resistance, metabolic syndrome, and T2DM. Here, FGF21 is linked to Insulin resistance.