SIRT1 and neurodegenerative disease: Bezafibrates were shown to restore levels of PGC-1α, PPARs and downstream genes (SIRT1, UCP1) with reversal of a similar BAT phenotype to the Mmut–/– TgINS-Alb-Mmut mice in mouse models of neurodegenerative diseases (87) and to induce hepatic autophagy and reduce lipogenesis and inflammation in GSD-1 murine and canine models (88).