We found that the expression of GYS1 and SLC7A11 were upregulated, while those of NCKAP1, NDUFS1, NUBPL, OXSM, RPN1, and SLC3A2 were downregulated in ccRCC tissues compared with those in the para-carcinoma tissues. The gene discussed is RPN1; the disease is nonpapillary renal cell carcinoma.