In a recent study including 358 individuals with incident HF and 347 age- and sex-matched control participants, CHIP was associated with higher natriuretic peptide levels, with subgroup analyses suggesting a nominally increased risk of incident HFpEF but not HFrEF among individuals younger than 65 years with vs without CHIP.22 Similarly, in a case-control study of 81 individuals with HFpEF vs 36 controls, Cochran et al23 found that those with HFpEF were significantly enriched for TET2 CHIP. This evidence concerns the gene TET2 and hydrops fetalis.