The same study found that mice modeled for TET2 CHIP had increased diastolic dysfunction, ventricular hypertrophy, and cardiac fibrosis in comparison with control mice.23 Our results corroborate and extend these findings by showing that TET2 CHIP was associated with incident HFpEF in a population-based sample, identifying TET2 CHIP as a strong and independent risk factor for new-onset HFpEF. This evidence concerns the gene STUB1 and cardiac hypertrophy.