STUB1 and hydrops fetalis: In a recent study including 358 individuals with incident HF and 347 age- and sex-matched control participants, CHIP was associated with higher natriuretic peptide levels, with subgroup analyses suggesting a nominally increased risk of incident HFpEF but not HFrEF among individuals younger than 65 years with vs without CHIP.22 Similarly, in a case-control study of 81 individuals with HFpEF vs 36 controls, Cochran et al23 found that those with HFpEF were significantly enriched for TET2 CHIP.