ICs are generally diagnosed at later stages, and the patients are more likely to present metastases in local lymph nodes than patients with a diagnosis of screen-detected cancer (SDC).4,5 In addition, ICs are more likely to be estrogen receptor (ER)–negative, progesterone receptor (PR)–negative,6,7 and triple-negative8 compared with SDC. The gene discussed is ESR1; the disease is primary ciliary dyskinesia.