It has been shown that PTVs in 5 of the 34 putative BC genes are strongly associated with risk of BC, placing PALB2 at the highest risk category together with BRCA1/2, and PTVs in ATM and CHEK2 in the moderate–high-risk category.15 Our results aligned with these findings; PTVs in the 5 major BC genes were significantly more common in patients compared with controls. The gene discussed is BRCA1; the disease is breast cancer.