For example, in their work of 2010, Passaperuma and colleagues [31] did not find any correlation between breast density grade and breast cancer risk in women carrying BRCA1/2 pathogenetic variants, while recently Han and colleagues [32] found that higher breast density is associated with having a positive breast cancer familial history in premenopausal women, data also reported by Ziv et al. [33]. The gene discussed is BRCA1; the disease is breast cancer.