The association between NF1 and tumour predisposition has been known for a long time, in particular specific associations, such as Optic Pathway Gliomas, Malignant Peripheral Nerve Sheath Tumors, pheochromocytomas, and neuroendocrine tumours, are reported; however, only in recent years, scientific literature has documented an increased incidence of BC and reduced survival for women with NF1 [6–8]. This evidence concerns the gene NF1 and neoplasm.