Mut p53 was also found to reprogram TNF-α signal transduction in tumor cells by binding tumor suppressor DAB2IP and downregulate its expression, that is, it promoted the activation of NF-κB and inhibited the activation of TNF-α on ASK1/JNK and finally promoted the survival of tumor cells and resisted the tumor killing effect mediated by CTL [44]. This evidence concerns the gene MAPK8 and neoplasm.