TP53 and non-small cell lung carcinoma: In addition, researchers have developed a redox-responsive nanoparticle (NP) platform that can effectively deliver p53-encoded mRNA to induce cell cycle arrest and apoptosis, significantly delay the proliferation of p53-null hepatocellular carcinoma and non-small cell lung cancer cells, and considerably improve the sensitivity of tumor cells to mTOR inhibitors [86].