Reportedly, ASAH2, a molecule highly expressed on the surface of tumor cells in a mouse colon cancer model, was also upregulated on the surface of MDSCs in TME and affected ferroptosis to promote the survival and accumulation of MDSCs by inhibiting the p53-Hmox1 pathway, consistent with the finding that silencing p53 reduced ROS levels in MDSCs and inhibited ferroptosis in MDSCs [66]. Here, TP53 is linked to malignant colon neoplasm.