In addition, the team of professors Duda DG and Shi J jointly developed an mRNA tumor-targeting nanoparticle strategy to restore the function of WT p53, which inhibited the proliferation of Mut p53 hepatocellular carcinoma cells while inhibiting tumor growth in combination with anti-PD-1 therapies and significantly enhanced antitumor immunity in hepatocellular carcinoma [93]. This evidence concerns the gene TP53 and hepatocellular carcinoma.