The overexpression of NAD-dependent deacetylase sirtuin 1 (SIRT1) in colorectal cancer promoted the expression of CXCL12 and CXCR4 on the surface of tumor cells and macrophages, respectively, facilitated the recruitment of M2-like TAMs and inhibited the cell proliferation and activity of CD8 + T cells, thus promoting colorectal cancer progression [58]. This evidence concerns the gene CD8A and colorectal cancer.