Moreover, the significant alteration in levels of MMP1, MMP3, MMP11, CHI3L1 and VEGF-A in non-diabetic fibroblasts between day 3 and day 7 after the wound were all abolished in diabetic M1 fibroblasts, and their expression levels were also significantly lower in diabetes (Fig. 4B). Here, MMP1 is linked to diabetes mellitus.