BCL2 and cancer: In addition, our study also found that overexpression of RNF32 inhibited apoptosis and the level of Bax/Bcl-2 apoptotic protein expression was significantly decreased in cancer cells (Fig. 12A, C), whereas knockdown of RNF32 enhanced apoptosis and the level of Bax/Bcl-2 apoptotic protein expression was significantly increased in cancer cells (Fig. 12B, D).