POLQ and colonic neoplasm: Previous literature reports have indicated that POLQ promotes cell growth and malignant progression in various cancers, including liver cancer, cervical cancer, breast cancer, and colon cancer (Allera-Moreau et al. 2012; Lemee et al. 2010; Pan et al. 2021; Pillaire et al. 2010; Shinmura et al. 2019).