In this paper, we found a deficiency in the antioxidant capacity of UUO or CIN kidney, previous research found UUO induction resulted in impaired renal function along with the downregulation of antioxidant proteins, such as NRF2, NQO1 and SOD, as a result, more ROS produced finally leads to oxidative stress and fibrosis [38, 39]. The gene discussed is SOD1; the disease is cervical squamous intraepithelial neoplasia.