Two examples include the encapsulation of asparaginase and thymidine phosphorylase, which are proposed for pancreatic cancer and mitochondrial neurogastrointestinal encephalomyopathy patients, respectively (Bax et al., 2019; Hammel et al., 2020; Robert et al., 2022). The gene discussed is ASPG; the disease is mitochondrial neurogastrointestinal encephalomyopathy.