Several transcription factors increase mTOR transcription including sirtuin 1 (SIRT1) [69], myeloid zinc finger 1 (MZF1) [70], and Nrf2 [71] while Ikaros represses mTOR transcription in B cell acute lymphoblastic leukemia [72]. The gene discussed is MTOR; the disease is B-cell acute lymphoblastic leukemia.