To identify genes regulated by the presence of SLPI, we first compared mock-infected Slpi−/− and Slpi+/+ mice (M-ko vs M-wt) which demonstrated few statistically significant differences at both the gene and pathway levels implying that in the absence of infection the transcriptional profiles of the bladder are very similar (Tables S1C and S2C). The gene discussed is SLPI; the disease is infection.