Interestingly, despite these differences in gene-level regulation, 71% of the pathways significantly regulated by infection were shared between Slpi+/+ (I-wt vs M-wt) and Slpi−/− (I-ko vs M-ko) mice, suggesting that Slpi−/− mice respond to a UTI similarly to Slpi+/+ (Fig. S3A; see also Table S2A and S2B). Here, SLPI is linked to infection.