For example, LncRNA‐EWSAT1 can induce apoptosis and inhibit proliferation by affecting RA‐FLS through downregulation of miR‐326 levels,12 LncRNA XIST binding to GATA1 leads to upregulation of CCN6, which causes RA to enter the inflammatory response phase by altering synovial fibroblast proliferation and angiogenic activity,13 and LncRNA HOTAIR affects FLSsl growth and apoptosis by regulating miR‐106b‐5p/Smad signaling and thus.14 This evidence concerns the gene XIST and rheumatoid arthritis.