Data from Li et al. demonstrated that PX can inhibit the level of oxidative stress and reverse aristolochic acid‐induced renal insufficiency through the Keap1‐Nrf2/HO‐1 signaling pathway, Nrf2 protein interactions inhibit Keap1 and regulate various genes including HO‐1.22 The gene discussed is HMOX1; the disease is Renal insufficiency.