Li et al. found that DEX preconditioning protects against myocardial ischemia/reperfusion injury by exerting antioxidant stress through activation of the Keap1/Nrf2 signal transduction pathway, while inhibition of the Keap1‐Nrf2/ARE signal transduction pathway reverses the protective effect of DEX preconditioning on myocardial ischemia/reperfusion injury.39 This evidence concerns the gene KEAP1 and myocardial ischemia.