As shown in this study, we evaluated HLA‐DR expression in monocytes, PD‐1 expression in T cells and their subsets, and the nCD64 index to diagnose sepsis and its prognosis and found that mHLA‐DR + , PD‐1 + CD4‐CD8‐T cells, and the nCD64 index had the best indicating performance, both individually and in combination. Here, CD8A is linked to Sepsis.