Among the 13 m5C regulators, nine (DNMT3A‐3B, DNMT1‐2, NSUN1‐7, DNMT3A, and NSUN5) were significantly related to prognosis of 417 AML samples derived from GEO database (GSE37642 data set). The gene discussed is NOP2; the disease is acute myeloid leukemia.