The roles among circ_0087199, miR‐527 and TLR4 in regulating LPS‐induced periodontitis cell injury was analyzed using quantitative real‐time polymerase chain reaction (qRT‐PCR), Western blot analysis analysis, cell counting kit‐8 (CCK‐8), 5‐Ethynyl‐2′‐deoxyuridine (EdU) assay, flow cytometry, enzyme‐linked immunosorbent assay (ELISA), malondialdehyde (MDA) assay kit and superoxide dismutase (SOD) activity assay kit. This evidence concerns the gene TLR4 and periodontitis.