Although research into AD neuropathologic change (ADNC) is mainly amyloid and tau centric, multiple copathologies are prevalent, including features of Lewy body disease, limbic‐predominant age‐related TDP43 encephalopathy (LATE) with or without hippocampal sclerosis, aging‐related tau astrogliopathy (ARTAG), or cerebrovascular disease (CVD) in the brains of either LOAD or DS‐related AD.16, 17. The gene discussed is MAPT; the disease is Dravet syndrome.