In human cells, ARRDC1 and ARRDC3 were shown to induce degradation of the mammalian homolog of Yki, YAP1, by recruiting the E3 ubiquitin ligase ITCH in renal cell carcinoma (Xiao et al., 2018), suggesting functional homology between human and Drosophila. This evidence concerns the gene YAP1 and renal cell carcinoma.