For instance, the Hippo signaling pathway, which impacts a variety of cellular processes such as metabolism, development, and tumor progression (Mo et al., 2014; Pei et al., 2015; Schütte et al., 2014; Wang et al., 2010; Zhi et al., 2012), was shown to be regulated by α-arrestin in both Drosophila (Kwon et al., 2013) and human cells (Xiao et al., 2018). The gene discussed is SAG; the disease is neoplasm.