In human cells, ARRDC1 and ARRDC3 were shown to induce degradation of the mammalian homolog of Yki, YAP1, by recruiting the E3 ubiquitin ligase ITCH in renal cell carcinoma (Xiao et al., 2018), suggesting functional homology between human and Drosophila. Here, YAP1 is linked to hereditary clear cell renal cell carcinoma.