In fact, despite a limited knowledge of their biology, α-arrestins have already been linked to a range of cellular processes and several major health disorders, such as diabetes (Batista et al., 2020; Wondafrash et al., 2020), cardiovascular diseases (Domingues et al., 2021), neurological disorders (Tsubaki et al., 2020), and tumor progression (Chen et al., 2020; Mohankumar et al., 2015; Oka et al., 2006), making them potential therapeutic targets. The gene discussed is SAG; the disease is cardiovascular disorder.