PICALM and Alzheimer disease: Other genes may also be associated with AD, such as clusterin (CLU), complement receptor-1 (CR1), bridging integrator 1 (BIN1), phosphatidylinositol binding clathrin assembly protein (PICALM), sortilin-related receptor L (SORL1), and triggering receptor expressed on myeloid cells 2 (TREM2) [103].