In addition, the mRNA level of CD163 (Figure 2c-2j) and ARG1 (Figure 2d-2k) (the markers of tumor-associated macrophage) was dramatically decreased in TDM and BMDM after B. thetaiotaomicron mixture, B. thetaiotaomicron culture medium, and acetic acid treatment, but not heat killed B. thetaiotaomicron or control bacteria E.coli. This evidence concerns the gene ARG1 and neoplasm.