However, it is noted that the initial stages of AD oftenmanifest symptoms similar to those observed in other types of dementia.26 Although analyzing APOE genotype, measuringAβ and tau in the blood or CSF, and employing imaging techniquesprovide valuable information for diagnosing AD, the complex samplingprocedure and high cost associated with these methods present practicalclinical challenges. The gene discussed is APOE; the disease is dementia.