In humans, the GABRA1 gene has been identified as the causative gene of developmental and epileptic encephalopathy-19 (DEE-19, OMIM* 615744) and the susceptibility genes of childhood absence epilepsy-4 (ECA-4, OMIM* 611136) and juvenile myoclonic epilepsy-5 (JME-5, OMIM* 611136). This evidence concerns the gene GABRA1 and juvenile myoclonic epilepsy.