Also, Liao demonstrated that increased methylation at R198 and R200 of the ECD of EGFR by protein arginine methyltransferase 1 (PRMT1) sustained signaling activation in the presence of cetuximab and conferred resistance to cetuximab treatment in both mouse orthotopic CRC xenograft model and CRC patients (Liao et al., 2015). Here, EGFR is linked to colorectal carcinoma.