CEACAM5 and colon carcinoma: However, in contrast to Lang et al. findings, Kwilas and others reported that cabozantinib monotherapy significantly reduced the frequency of Tregs and MDSCs in the spleen (Kwilas et al., 2014) but significantly increased infiltrating CD8+ T cells of human carcinoembryonic antigen (CEA)-Tg C57/BL6 mice as well as significantly upregulated the expression of MHC-I molecules on tumor cells of the murine colon carcinoma cell line MC38-CEA, thus increasing the potential for antigen presentation and T-cell recognition of the tumor cells (Kwilas et al., 2014).