c-MET inhibition using savolitinib significantly suppressed sphere formation by the patient-derived CRC cells with low ABHD5 and high MET expression, indicating that inhibiting c-MET is an effective strategy for eradicating the CRC stem cell compartment, characterized as low ABHD5 and high c-MET expression (Gu et al., 2021). The gene discussed is MET; the disease is colorectal carcinoma.