The aim of the present study was to evaluate in surgically treated ACC patients under AMT: (i) the changes in LH, SHBG, TT, and cFT levels and the prevalence and type of hypogonadism during AMT, as well as (ii), for the first time, the sexual function before and after ART in patients with hypogonadism. The gene discussed is PLOD1; the disease is adrenal cortex carcinoma.