AXIN2 and adrenal cortex carcinoma: In adrenocortical carcinoma, aberrant β-catenin status correlates with upregulation of its target genes LEF1, AXIN2, and ISM1, which are not increased in ACA, indicating that transcriptionally active β-catenin influences proliferative phenotype and the transcriptional level of TCF/LEF target genes (15, 16).