Compared to the combination of PNU-74654 and AMG900, the impact on, the combination of PNU-74654 and Alisertib was observed more effective in suppressing the cell viability of NCI-H295R cells, implying that the function generated by AMG900 on cell viability of adrenocortical carcinoma may be caused by the inhibition of AURKA. Here, AURKA is linked to adrenal cortex carcinoma.