Besides secreted factors, key cellular signaling pathways such as TGFB, NFKB, PI3K/AKT have been identified as a central hub in mediating the crosstalk between the cancer cells and CAFs important for tumor metastasis (Erez et al., 2010; Sharon et al., 2015; Ringuette Goulet et al., 2018). The gene discussed is NFKB1; the disease is cancer.