Interestingly, CAF states 2 and 3 (inflammatory/adipogenic CAFs) were shown to mediate crosstalks with tumor endothelial cells notably via NOTCH1/2/3_JAG1/2/DLL4 pathways reiterating the role of NOTCH signaling in CAF-mediated angiogenesis (Luo et al., 2022). The gene discussed is DLL4; the disease is neoplasm.