Mechanistically, the effect of activated NOTCH1 in fibroblasts to suppress melanoma growth and angiogenesis has been shown to be mediated by the secretion of wnt-induced secreted protein-1 (WSP-1) and identifying the NOTCH1-mediated WISP1 as an important player (Shao et al., 2011). This evidence concerns the gene NOTCH1 and melanoma.