NOTCH1 and neoplasm: Accordingly, NOTCH1 signaling in CAFs has largely been shown to have a tumor suppressive effect (Shao et al., 2011; Shao H. et al., 2015; Shao et al., 2021) with some reports indicating its pro-tumorigenic effect as well (Hoare et al., 2016; Nabet et al., 2017).