IL1B and neoplasm: Further molecular studies interestingly demonstrated that NRLP3-mediated secretion of IL1-b by the CAFs was key for mediating tumor growth and metastasis in vivo since, co-injection of (nrlp3−/−) tumor cells with either (nrlp3−/−) or (il1b−/−) led to reduced lung metastasis (Ershaid et al., 2019).