Alterations in FBN1 gene also lead to MASS (mitral valve, myopia, aorta, skin and skeletal condition) phenotype (Fusco et al., 2019), Marfanoid-progeroid-lipodystrophy, Acromic dysplasia, Stiff skin syndrome (SSS), Geleoplastic dysplasia, Weill-Marchesani syndrome (WMS) (Sengle et al., 2012; Sakai and Keene, 2019; Al Motawa et al., 2021; Marzin et al., 2021), which are not related to MFS (Loeys et al., 2010a). This evidence concerns the gene FBN1 and stiff skin syndrome.