In two patients, who did not show driver mutations in primary tumours, EGFR mutations were detected in the CSF, including 19del mutation in patient 7 (which later changed to L858R mutation after 28 months), and L858R+MET amplification in patient 25 (which later changed to G719S+E709A+MET amplification after 67 months). This evidence concerns the gene EGFR and neoplasm.