IFNA1 and viral infectious disease: It is now documented that the interferon response and score are only activated during the very early phase of viral infection and will largely be subsided at the end of the first week (55, 56, 59).Therefore our data further confirmed the importance of the timeframe for sample collection and examination of IFN genes Similarly, contradictory results of treatment with various exogenous interferon in different trials could be due to difference in the outcome measures and timing of the interferon administration.