Similar to the training dataset and validation dataset, KIF20B was expressed at a relatively low level in WT pancreatic cancer cells BxPC-3 (p < 0.05), while AKR1A1 was highly expressed in WT pancreatic cancer cells (type BxPC-3), compared with mutant types, such as MIA Paca-2(KRAS G12C mut), PANC-1(KRAS G12D mut), SW1990(KRAS G12D mut) and Capan-2(KRAS G12V mut)(p < 0.01). This evidence concerns the gene KRAS and familial pancreatic carcinoma.