Yuan and Shen (2021) showed in a previous experiment that the supplementation of probiotics (Bacteroides vulgatus ATCC8482) in mice with OVX‐induced osteoporosis for 8 consecutive weeks could correct the disorder of gut microbiota, inhibit the LPS/TLR‐4/p‐NF‐κB pathway in colon, reduce the level of TNF‐α in serum, and then inhibit the bone loss and the destruction of bone microstructure. The gene discussed is TLR4; the disease is osteoporosis.