Finally, we found that the top 10 connected hub genes were TNF, IL1B, signal transducerand activator of transcription 1 (STAT1), toll-like receptor 4 (TLR4), toll-like receptor 2 (TLR2), interferon regulatory factor (IRF7), interferon regulatory factor (CXCL10), myeloid differentiation factor88 (MYD88), CD44, CD68 (Figure 2E), indicating these 10 genes maybe the potential regulators of EndMT during atherosclerosis. This evidence concerns the gene IRF7 and atherosclerosis.