TLR4 and atherosclerosis: Finally, we found that the top 10 connected hub genes were TNF, IL1B, signal transducerand activator of transcription 1 (STAT1), toll-like receptor 4 (TLR4), toll-like receptor 2 (TLR2), interferon regulatory factor (IRF7), interferon regulatory factor (CXCL10), myeloid differentiation factor88 (MYD88), CD44, CD68 (Figure 2E), indicating these 10 genes maybe the potential regulators of EndMT during atherosclerosis.