SIGLEC12 and neoplasm: We further elucidated the significance of SIGLEC12 expression in tumour nodal metastasis, result showed a statistically significant increase in the metastases according to the tumour, node, metastasis (TNM) staging framework, N0 in KIRC (Fig. 3I) and N0, N1, N2 in KIRP (Fig. 3J).