Although there is still no evidence that relates CCN6 to LUAD, CCN6 have been shown to play a crucial role in gastrointestinal cancers (Thorstensen et al., 2003), breast cancers (Djomehri et al., 2020) and chondrosarcoma metastasis to lung (Tzeng et al., 2018). Here, CCN6 is linked to breast carcinoma.