After the intervention treatment with Tsp43, the serum IL-1β and TNF-α of mice were significantly reduced (P < 0.001), while the contents of IL-1β and TNF-α were not changed by HiTsp43 (P  > 0.05), which indicated the potential therapeutic effects of Tsp43 on RA. This evidence concerns the gene IL1B and rheumatoid arthritis.