Since VWF:RCo levels were closely correlated with VWF:Ag levels in patients with AS (rs = 0.869, P < .001), patients with PAD (rs = 0.800, P < .001), and control patients (rs = 0.924, P < .001) (Figure 3), the high VWF:RCo levels often observed in patients with AS could be due to rather high VWF:Ag levels. The gene discussed is VWF; the disease is peripheral arterial disease.