VWF and peripheral arterial disease: When VWF:RCo/VWF:Ag of <0.7 is used for the diagnosis of AS-induced AVWS, we need to consider following: patients with PAD exhibited the VWF:RCo/VWF:Ag of around 0.8, which is close to 0.7; VWF:RCo/VWF:Ag ratios were correlated with the severity of AS although the tilt angle of the slope of the regression line was rather low, compared to that of VWF large multimer indices.