VWF and platelet-type von Willebrand disease: Although there are no clear diagnostic criteria for AVWS, several articles outline the following criteria for the diagnosis of AVWS [[31], [32], [33]]: a bleeding disorder without family and personal histories of von Willebrand disease; VWF:Ag, VWF:RCo/VWF:Ag, or VWF high molecular weight (large) multimers are reduced/absent.