We here found that the VWF large multimer indices <80% may indicate AVWS for following reasons: (1) the indices of <80% exhibited an apparent reduction in the large multimers (Figure 1A); (2) 59.0% of patients with severe AS, while no patients with PAD or control patients except 2 patients exhibited the indices of <80% (Figure 1C–E). Here, VWF is linked to aortic stenosis.