Furthermore, VWF:RCo/VWF:Ag ratios were positively correlated with VWF large multimer indices in patients with AS (rs = 0.470, P < .001), and in control patients (rs = 0.542, P < .001), while they did not correlate in patients with PAD (rs = 0.217, P = .28) (Figure 4). The gene discussed is VWF; the disease is peripheral arterial disease.