With the presence of MetS, age‐adjusted and sex‐adjusted values were significantly higher for CF‐PWV (9.57 ± 0.06 vs. 8.65 ± 0.10, p−value < .001), but such difference was not found for CAVI (8.34 ± 0.03 vs. 8.29 ± 0.04, p−value = .40). Here, CFTR is linked to metabolic syndrome.