METTL1 and acute myeloid leukemia: Further OPP labeling experiments showed decreased levels of OPP mean fluorescence intensity (MFI) in AML cells transfected with tRNAs isolated from METTL1 knockdown cells compared to those from METTL1 control cells (Fig. 6E–G), suggesting that the m7G dysregulated tRNA methylome also affected the translation function of cellular tRNA pools.