WDR4 and acute myeloid leukemia: To further investigate the regulating mechanism of the collaborative expression of METTL1 and WDR4 in AML, we first analyzed the transcriptome datasets of acute myeloid leukemia (LAML) from the Cancer Genome Atlas (TCGA) and confirmed that the transcription levels of METTL1 were positively correlated to WDR4 (r = 0.6064, p < 0.0001, Fig. 3E).