METTL1 and acute myeloid leukemia: However, when transfected with the isolated tsRNAs (30–40 nt) fragments from METTL1 knockdown cells into AML cells, the overall translation efficiency in AML cells was not affected (Additional file 4: Fig. S4), indicating that the molecular regulation mechanism of tsRNAs might not involve in cellular nascent protein synthesis as tRNAs in AML cells and more investigations should be performed to unveil the underline mechanism of tsRNA in AML leukaemogenesis.