METTL1 and acute myeloid leukemia: In our study, we found a negative correlation between DNA methylation levels and mRNA expression of METTL1 in AML patients and downregulation of METTL1 expression upon Tet inhibitor (Bobcat339 hydrochloride) [61] treatment, however, the exact molecular mechanism of DNA methylation modifiers in regulating METTL1 expression still need further investigation.