Moreover, using the acute myeloid leukemia (LAML) datasets from the Cancer Genome Atlas (TCGA), we found that poor patient survival was shown in AML patients which had significantly high expression levels of METTL1 or WDR4 (Fig. 1G), indicating potential functions of METTL1 and WDR4 in the regulation of AML progression. The gene discussed is WDR4; the disease is acute myeloid leukemia.