METTL1 and acute myeloid leukemia: Compared to the controls, the level of m7G on tRNA was significantly decreased in METTL1 knockdown AML cells, while the abundances of other types of RNA modification were almost not affected (Fig. 4B–D and Additional file 3: Fig. S3A), indicating that METTL1 specifically affects m7G abundance on tRNA in AML cells.