METTL1 and acute myeloid leukemia: Moreover, quantitative proteomics experiment revealed that the downregulated proteins induced by knockdown of METTL1 were enriched in the protein translation process (e.g., protein complex assembly, protein complex, protein dephosphorylation) and a series of enzyme activity (protein tyrosine/serine/threonine phosphatase activity, glutamine-tRNA ligase activity, glutaminyl-tRNA aminoacylation) (Fig. 5D, E), which consist with the above results that METTL1 regulate the global translation in AML cells.