In recent years, an increasing number of studies revealed that dysregulations of METTL1/WDR4-mediated tRNA m7G modification played an important biological function in human malignancies such as liver cancer, colorectal cancer, and lung cancer, including tumor progression and chemotherapeutic sensitivity which served as a promising candidate target for the prevention and treatment of tumors [27, 33, 35, 57, 58]. This evidence concerns the gene WDR4 and lung cancer.