Furthermore, the expression of SPI1 showed negative correlation with that of FTO in normal blood tissues from the Genotype-Tissue Expression Project (GTEx, n = 444, Additional file 1: Fig. S1G), BM samples from patients with AML from the Analysis of the Cancer Genome Atlas (TCGA) database (n = 173, Additional file 1: Fig. S1H), and BM samples from patients with t(8;21) AML (n = 26, Fig. 1M). Here, FTO is linked to acute myeloid leukemia.