A transcriptome sequencing of primary BM cells harvested from AML patients at diagnosis (GSE97393) [38] showed that mRNA expression levels of FTO were significantly higher in patients with poor response to Ara-C (n = 11) in vivo compared with high responders (n = 10; Fig. 4A), suggesting a potential role of FTO in Ara-C resistance. This evidence concerns the gene FTO and acute myeloid leukemia.