We further found that the high expression of IGFBP2 (insulin-like growth factor binding protein 2), which was listed in Fig. 5E, was significantly upregulated in patients with t(8;21) AML (n = 30) compared with normal control (n = 9, GSE30285 and GSE34814, Additional file 1: Fig. S5E). This evidence concerns the gene IGFBP2 and acute myeloid leukemia.