Rescue experiments conducted with AML1-ETO9a AML mouse model also revealed a significant restoration in the infiltration of leukemic cells in PB, BM, liver and spleen when Igfbp2 was overexpressed in Fto-knockdown cells (Fig. 8E–G and Additional file 1: Fig. S8B–C). The gene discussed is IGFBP2; the disease is acute myeloid leukemia.