We found that 11 hypo-up (CEP57, FTX, ZC3H11A, TERF2, PAX6, IGFBP2, BTBD3, NOA1, VKORC1L1, GCC2, and YAF2) and 7 hypo-down (SSU72, FBXW5, SERF2, Rab3A, TCEA3, TSPAN14, and GGT1) genes demonstrated a significantly positive and negative correlation in expression, respectively, with FTO in TCGA AML datasets (Fig. 5E and Additional file 2: Table S2). This evidence concerns the gene IGFBP2 and acute myeloid leukemia.