Among the top 10 co-cited references, four are associated with neuroinflammation [17, 19, 22, 26]; one pioneered the identification of a new type of microglia ( DAM) and explored the way it is activated [27]; one reveals that TREM2 variation has a strong link with an increased risk of AD [28], one explores the treatment of AD by injection of targeted exosomes [20]; one emphasizes the critical function of the brain microenvironment in the onset and progression of AD [29]; one is mainly on amyloid protein hypothesis [30]. Here, TREM2 is linked to Alzheimer disease.