NLRP3 and Alzheimer disease: In 2008, a Hickman, Se’s article published by Journal of Neuroscience concluded that pro-inflammatory cytokines produced by amyloid-β deposition can impair microglial clearance function as AD progresses [23], which provided ideas for Heneka, Mt to study the effect of NLRP3 deficiency on the phagocytosis of microglia in vivo.