RUNX2 and periodontitis: In order to determine the effect of METTL3 in periodontitis, a known methyltransferase inhibitor SAH was used to treat LPS-stimulated osteoblasts in vitro and injected into ligature-induced periodontitis model in vivo. SAH suppressed the protein levels of β-catenin, c-MYC, and RUNX2, whereas CHIR rescued the effect of SAH in osteoblasts (Additional file 1: Fig. S5A).