So far, the markers copeptin (COPAVP) [6], midregional adrenomedullin (MRproADM) [7], midregional proatrial naturetic peptide [8] and fibrinogen [9] that can be measured in blood, have been examined primarily in patients with advanced COPD with regard to mortality risk [6, 8, 10]. The gene discussed is AVP; the disease is chronic obstructive pulmonary disease.