For example, one study showed that 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4 (PFKFB4) binds to FBXO28 to regulate the ubiquitination and proteasomal degradation of HIF-1α, promoting HIF-1α signaling in glioblastoma [16]. This evidence concerns the gene HIF1A and glioblastoma.