The findings revealed that higher expression of B7-H4 (HR = 3.276, 95% CI 1.335–8.041, P = 0.010) and higher CD68+ macrophage infiltration (HR = 3.775, 95% CI 1.419–10.044, P = 0.008) were independent prognostic factors for patients with NSCLC brain metastases (Table 3). This evidence concerns the gene VTCN1 and non-small cell lung carcinoma.