HAVCR2 and acute myeloid leukemia: In most types of AML, especially HL-60 (the Myeloblastic (M2) subtype cell line) [6] and THP-1 (the Monocytic (M5) subtype cell line) [7], TIM-3 is expressed on leukemic stem cells (LSCs), but not on normal hematopoietic stem cells (HSCs) [8–10].