Alexandr Prokhorov et al., have shown that the TIM-3 activation by galectin-9, triggers growth factor type responses by stimulation of the PI-3 K/mTOR pathway in AML cells especially in THP-1 cells and also VEGF production and induced S2448 mTOR phosphorylation were shown time-dependent [20]. This evidence concerns the gene VEGFA and acute myeloid leukemia.